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Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide

Abstract:

Many chronic degenerative diseases result from aggregation of misfolded polypeptides to form amyloids. Many amyloidogenic polypeptides are surfactants and their assembly can be catalysed by hydrophobic-hydrophilic interfaces (an air-water interface in-vitro or membranes in-vivo). We recently demonstrated the specificity of surface-induced amyloidogenesis but the mechanisms of amyloidogenesis and more specifically of adsorption at hydrophobic-hydrophilic interfaces remain poorly understood. Th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep32124

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Institution:
University of Oxford
Oxford college:
Lincoln College
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More from this funder
Funding agency for:
Jean, L
Grant:
RF201
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Issue:
32124
Publication date:
2016-08-18
Acceptance date:
2016-08-02
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Source identifiers:
637485
Pubs id:
pubs:637485
UUID:
uuid:6ed729f5-0ddc-480c-bf55-417bf4909e6e
Local pid:
pubs:637485
Deposit date:
2016-08-05

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