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Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide

Abstract:

Many chronic degenerative diseases result from aggregation of misfolded polypeptides to form amyloids. Many amyloidogenic polypeptides are surfactants and their assembly can be catalysed by hydrophobic-hydrophilic interfaces (an air-water interface in-vitro or membranes in-vivo). We recently demonstrated the specificity of surface-induced amyloidogenesis but the mechanisms of amyloidogenesis and more specifically of adsorption at hydrophobic-hydrophilic interfaces remain poorly understood. Th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep32124

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Department:
Lincoln College
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Department:
Oxford, MSD, Pathology Dunn School
Lee, Chiu Fan More by this author
Hodder, Peter More by this author
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Department:
Oxford, MPLS, Department of Zoology
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Funding agency for:
Jean, Létitia
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Issue:
32124
Acceptance date:
2016-08-02
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:637485
URN:
uri:6ed729f5-0ddc-480c-bf55-417bf4909e6e
UUID:
6ed729f5-0ddc-480c-bf55-417bf4909e6e
Local pid:
pubs:637485

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