Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis.

Journal article

Polycyclic polyether natural products have fascinated chemists and biologists alike owing to their useful biological activity, highly complex structure and intriguing biosynthetic mechanisms. Following the original proposal for the polyepoxide origin of lasalocid and isolasalocid and the experimental determination of the origins of the oxygen and carbon atoms of both lasalocid and monensin, a unified stereochemical model for the biosynthesis of polyether ionophore antibiotics was proposed. Th...

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Authors: Hotta, K; Chen, X; Paton, R; Minami, A; Li, H

• Publication status: Published
• Journal: Nature
• Volume: 483
• Issue: 7389
• Pages: 355-358
• Publication date: 2012-03-01
• DOI: 10.1038/nature10865
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Cyclization; Protein Conformation; Biological Agents; Epoxide Hydrolases; Biocatalysis; Lasalocid; Crystallography, X-Ray; Structure-Activity Relationship; Ethers; Models, Molecular; Molecular Structure; Hydrogen Bonding; Streptomyces