Journal article
Treatment associated inflammatory deterioration in tuberculous meningitis: unpicking the paradox
- Abstract:
-
Ever since the advent of anti-tuberculosis chemotherapy in the late 1940s, physicians have recognized that in some patients the symptoms and signs of tuberculosis worsen after the start of treatment. These clinical manifestations have been called ‘paradoxical reactions’, because they occur despite effective anti-microbial therapy. Their pathogenesis is poorly understood, but they are broadly considered to be caused by excessive inflammation to dead and dying bacteria [1]. Paradoxical reacti...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Journal of Infectious Diseases Journal website
- Volume:
- 215
- Issue:
- 5
- Pages:
- 665–667
- Publication date:
- 2016-12-08
- Acceptance date:
- 2016-12-08
- DOI:
Item Description
- Pubs id:
-
pubs:666087
- UUID:
-
uuid:6ed0c595-1e63-4cc4-ae37-ee8e8c1b1d34
- Local pid:
- pubs:666087
- Source identifiers:
-
666087
- Deposit date:
- 2016-12-15
Terms of use
- Copyright holder:
- Nguyen and Thwaites
- Copyright date:
- 2016
- Notes:
- © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.This is the accepted manuscript version of the article. The final version is available online from Oxford University Press at: https://doi.org/10.1093/infdis/jiw565
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