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Treatment associated inflammatory deterioration in tuberculous meningitis: unpicking the paradox

Abstract:

Ever since the advent of anti-tuberculosis chemotherapy in the late 1940s, physicians have recognized that in some patients the symptoms and signs of tuberculosis worsen after the start of treatment. These clinical manifestations have been called ‘paradoxical reactions’, because they occur despite effective anti-microbial therapy. Their pathogenesis is poorly understood, but they are broadly considered to be caused by excessive inflammation to dead and dying bacteria [1]. Paradoxical reacti...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jiw565

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Thwaites, G
Nguyen, T
Publisher:
Oxford University Press
Journal:
Journal of Infectious Diseases More from this journal
Volume:
215
Issue:
5
Pages:
665–667
Publication date:
2016-12-08
Acceptance date:
2016-12-08
DOI:
Pubs id:
pubs:666087
UUID:
uuid:6ed0c595-1e63-4cc4-ae37-ee8e8c1b1d34
Local pid:
pubs:666087
Source identifiers:
666087
Deposit date:
2016-12-15

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