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Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study

Abstract:

BACKGROUND: Lactic acidosis with an elevated lactate-pyruvate ratio suggesting anoxia is a common feature of severe falciparum malaria. High lactate levels are associated with parasitized erythrocyte sequestration in the microcirculation. To assess if there is an additional contribution to hyperlactataemia from relatively inadequate total oxygen delivery, oxygen consumption and delivery were investigated in patients with malaria.

METHODS: Adult Ban...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-019-2733-y

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-1869-8307
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More from this funder
Name:
National Health and Medical Research Council
Grant:
605807
Publisher:
Biomed Central
Journal:
Malaria journal More from this journal
Volume:
18
Issue:
1
Article number:
97
Publication date:
2019-03-25
Acceptance date:
2019-03-18
DOI:
ISSN:
1475-2875
Pmid:
30909915
Language:
English
Keywords:
Pubs id:
pubs:991690
UUID:
uuid:6eb04e29-34ed-435e-8a3b-65ad72551207
Local pid:
pubs:991690
Source identifiers:
991690
Deposit date:
2019-04-18

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