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Multi-scale coarse-graining for the study of assembly pathways in DNA-brick self-assembly

Abstract:

Inspired by recent successes using single-stranded DNA tiles to produce complex structures, we develop a two-step coarse-graining approach that uses detailed thermodynamic calculations with oxDNA, a nucleotide-based model of DNA, to parametrize a coarser kinetic model that can reach the time and length scales needed to study the assembly mechanisms of these structures. We test the model by performing a detailed study of the assembly pathways for a two-dimensional target structure made up of 3...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1063/1.5019344

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics; Theoretical Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Oxford college:
Queens College
Role:
Author
ORCID:
0000-0002-2226-9524
Publisher:
AIP Publishing Publisher's website
Journal:
Journal of Chemical Physics Journal website
Volume:
148
Issue:
13
Article number:
134910
Publication date:
2018-04-05
Acceptance date:
2018-02-28
DOI:
EISSN:
1089-7690
ISSN:
0021-9606
Keywords:
Pubs id:
pubs:810291
UUID:
uuid:6eacc38d-58e4-437f-84bb-beb285c35488
Local pid:
pubs:810291
Source identifiers:
810291
Deposit date:
2018-04-05

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