Localisation and functional significance of ryanodine receptors during beta-adrenoceptor stimulation in the guinea-pig sino-atrial node.

Journal article

OBJECTIVE: Recent evidence shows that calcium released from the sarcoplasmic reticulum (SR) plays an important role in the regulation of heart rate. The aim of this study was to investigate the subcellular distribution of ryanodine receptors in the guinea-pig sino-atrial (SA) node and to determine their functional role in the regulation of pacemaker frequency in response to beta-adrenoceptor stimulation. METHODS: Monoclonal antibodies raised against the cardiac ryanodine receptor were used wi...

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Authors: Rigg, L; Heath, B; Cui, Y; Terrar, D

• Publication status: Published
• Journal: Cardiovascular research
• Volume: 48
• Issue: 2
• Pages: 254-264
• Publication date: 2000-11-01
• DOI: 10.1016/s0008-6363(00)00153-x
• EISSN: 1755-3245
• ISSN: 0008-6363
• Language: English
• Keywords: Adrenergic beta-Agonists; Ryanodine Receptor Calcium Release Channel; Cells, Cultured; Stimulation, Chemical; Sinoatrial Node; Antibodies, Monoclonal; Dose-Response Relationship, Drug; Immunohistochemistry; Animals; Isoproterenol; Action Potentials; Sarcoplasmic Reticulum; Male; Microscopy, Confocal; Guinea Pigs; Calcium; Patch-Clamp Techniques; Ryanodine