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Syncytiotrophoblast Extracellular Vesicles from Pre-Eclampsia Placentas Differentially Affect Platelet Function

Abstract:

Pre-eclampsia (PE) complicates around 3% of all pregnancies and is one of the most common causes of maternal mortality worldwide. The pathophysiology of PE remains unclear however its underlying cause originates from the placenta and manifests as raised blood pressure, proteinuria, vascular or systemic inflammation and hypercoagulation in the mother. Women who develop PE are also at significantly higher risk of subsequently developing cardiovascular (CV) disease. In PE, the failing endoplasmi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0142538

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Role:
Author
ORCID:
0000-0001-7537-1509
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Role:
Author
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Contributors

Role:
Editor
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
10
Issue:
11
Pages:
e0142538
Publication date:
2015-11-09
Acceptance date:
2015-10-22
DOI:
ISSN:
1932-6203
Pubs id:
pubs:579470
URN:
uri:6e94ceca-a425-4314-87c9-c390d3248c29
UUID:
uuid:6e94ceca-a425-4314-87c9-c390d3248c29
Local pid:
pubs:579470

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