Changes in the incidence and predictors of human immunodeficiency virus-associated dementia in the era of highly active antiretroviral therapy.

Journal article

OBJECTIVE: Though effective anti-human immunodeficiency virus (HIV) therapies are now available, they have variable penetration into the brain. We therefore aimed to assess changes over calendar time in the risk for HIV-associated dementia (HIV-D), and factors associated with HIV-D risk. METHODS: Using Concerted Action on Seroconversion to AIDS and Death in Europe (CASCADE) data, we analyzed factors associated with time from HIV seroconversion to HIV-D using Cox models with time-updated covar...

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Authors: Bhaskaran, K; Mussini, C; Antinori, A; Walker, A; Dorrucci, M

• Publication status: Published
• Journal: Annals of neurology
• Volume: 63
• Issue: 2
• Pages: 213-221
• Publication date: 2008-02-01
• DOI: 10.1002/ana.21225
• EISSN: 1531-8249
• ISSN: 0364-5134
• Language: English
• Keywords: Risk Factors; Viral Load; CASCADE Collaboration; HIV Infections; Homosexuality, Male; Survival Analysis; Risk-Taking; CD4 Lymphocyte Count; HIV Seropositivity; Age of Onset; Adult; Middle Aged; Sexual Behavior; Prognosis; Age Factors; Male; Proportional Hazards Models; Time Factors; Disease Progression; Europe; Antiretroviral Therapy, Highly Active; Humans; Severity of Illness Index; AIDS Dementia Complex; Female; Incidence