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Changes in the incidence and predictors of human immunodeficiency virus-associated dementia in the era of highly active antiretroviral therapy.

Abstract:

OBJECTIVE: Though effective anti-human immunodeficiency virus (HIV) therapies are now available, they have variable penetration into the brain. We therefore aimed to assess changes over calendar time in the risk for HIV-associated dementia (HIV-D), and factors associated with HIV-D risk. METHODS: Using Concerted Action on Seroconversion to AIDS and Death in Europe (CASCADE) data, we analyzed factors associated with time from HIV seroconversion to HIV-D using Cox models with time-updated covar...

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Publication status:
Published

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Publisher copy:
10.1002/ana.21225

Authors


Bhaskaran, K More by this author
Mussini, C More by this author
Antinori, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Dorrucci, M More by this author
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Journal:
Annals of neurology
Volume:
63
Issue:
2
Pages:
213-221
Publication date:
2008-02-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:6e86ead6-a6a2-4c08-957c-1fae8fa761db
Source identifiers:
422639
Local pid:
pubs:422639

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