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Predicting brain atrophy from tau pathology: a summary of clinical findings and their translation into personalized models

Abstract:

For more than 25 years, the amyloid hypothesis–the paradigm that amyloid is the primary cause of Alzheimer’s disease–has dominated the Alzheimer’s community. Now, increasing evidence suggests that tissue atrophy and cognitive decline in Alzheimer’s disease are more closely linked to the amount and location of misfolded tau protein than to amyloid plaques. However, the precise correlation between tau pathology and tissue atrophy remains unknown. Here we integrate multiphysics modeling and Baye...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.brain.2021.100039

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author

Contributors

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Name:
Engineering and Physical Sciences Research Council
Grant:
EP/R020205/1
Publisher:
Elsevier
Journal:
Brain Multiphysics More from this journal
Volume:
2
Article number:
100039
Publication date:
2021-10-12
Acceptance date:
2021-10-05
DOI:
EISSN:
2666-5220
Language:
English
Keywords:
Pubs id:
1199080
Local pid:
pubs:1199080
Deposit date:
2021-10-06

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