Apoptosis after experimental stroke: fact or fashion?

Journal article

Abstract:: This review examines the appearance of hallmarks of apoptosis following experimental stroke. The reviewed literature leaves no doubt that ischemic cell death in the brain is active, that is, requires energy; is gene directed, that is, requires new gene expression; and is capase-mediated, that is, uses apoptotic proteolytic machinery. However, sufficient differences to both classical necrosis and apoptosis exist which prevent easy mechanistic classification. It is concluded that ischemic cell ...
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Role:

Author

Institution:

University of Oxford

Division:

MSD

Department:

RDM

Sub department:

Stroke and Geratology

Role:

Author

Language:: English
Keywords:: Brain Ischemia

Necrosis

Apoptosis

Animals

Caspases

Mitochondria

Cell Nucleus

Disease Models, Animal

Stroke

Gene Expression Regulation

DNA Fragmentation

Humans
Pubs id:: pubs:79283
UUID:: uuid:6e757cda-bdcd-497c-ac06-d0dc4a11acb8
Local pid:: pubs:79283
Source identifiers:: 79283
Deposit date:: 2012-12-19

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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