Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.
Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly. Here, we find that the functions of PAXX and XLF in V(D)J recombination are masked by redundant joining activities. Thus, combined PAXX and XLF deficiency leads to an inability to join RAG-cleaved DNA ends. Additionally, we demonstrate that PAXX function in V(D)J recombination depends on its inte...Expand abstract
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- Peer reviewed
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- Lescale et al
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- © 2016 the Author(s). Open Access funded by European Research Council; article available under a Creative Commons BY-NC-ND license.
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