Journal article icon

Journal article

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.

Abstract:

Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly. Here, we find that the functions of PAXX and XLF in V(D)J recombination are masked by redundant joining activities. Thus, combined PAXX and XLF deficiency leads to an inability to join RAG-cleaved DNA ends. Additionally, we demonstrate that PAXX function in V(D)J recombination depends on its inte...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.celrep.2016.08.069

Authors


More by this author
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
Expand authors...
More from this funder
Grant:
C6/A18796; C6946/A14492; C6/A18796
Institut Pasteur More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Publication date:
2016-09-02
Acceptance date:
2016-08-23
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:641966
URN:
uri:6e56c61a-3bc6-4237-b2c3-83bda2925f2b
UUID:
uuid:6e56c61a-3bc6-4237-b2c3-83bda2925f2b
Local pid:
pubs:641966

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP