Journal article
Feedback activation of HER3 attenuates response to EGFR inhibitors in colon cancer cells.
- Abstract:
-
The EGFR inhibitor cetuximab is approved for the treatment of colorectal cancer. However, both innate and acquired resistance mechanisms, including compensatory feedback loops, limit its efficacy. Nevertheless, the emergence of these feedback loops has remained largely unexplored to date. Here, we showed feedback upregulation of HER3 and induction of HER3 phosphorylation after cetuximab treatment in colon cancer cells. We also showed that this upregulation occurs, at least partly, through AKT...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- Impact Journals Publisher's website
- Journal:
- Oncotarget Journal website
- Volume:
- 8
- Issue:
- 3
- Pages:
- 4277-4288
- Publication date:
- 2016-12-01
- Acceptance date:
- 2016-11-30
- DOI:
- EISSN:
-
1949-2553
- Pmid:
-
28032592
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:667648
- UUID:
-
uuid:6e40e201-d231-47e8-9713-1de6b6ad5202
- Local pid:
- pubs:667648
- Source identifiers:
-
667648
- Deposit date:
- 2018-03-09
Terms of use
- Copyright holder:
- Vojnovic et al
- Copyright date:
- 2016
- Notes:
- All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
- Licence:
- CC Attribution (CC BY)
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