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Journal article

Feedback activation of HER3 attenuates response to EGFR inhibitors in colon cancer cells.

Abstract:

The EGFR inhibitor cetuximab is approved for the treatment of colorectal cancer. However, both innate and acquired resistance mechanisms, including compensatory feedback loops, limit its efficacy. Nevertheless, the emergence of these feedback loops has remained largely unexplored to date. Here, we showed feedback upregulation of HER3 and induction of HER3 phosphorylation after cetuximab treatment in colon cancer cells. We also showed that this upregulation occurs, at least partly, through AKT...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
UK Department of Health
Grant:
C1519/A10331
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Name:
Medical Research Council
Grant:
C1519/A10331
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Name:
Seventh Framework Programme
Grant:
259881
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Name:
Engineering and Physical Sciences Research Council
Grant:
EP/C546113/1
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Name:
Cancer Research UK
Grant:
C1519/A10331
Publisher:
Impact Journals
Journal:
Oncotarget More from this journal
Volume:
8
Issue:
3
Pages:
4277-4288
Publication date:
2016-12-01
Acceptance date:
2016-11-30
DOI:
EISSN:
1949-2553
Pmid:
28032592

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