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The HIV protease inhibitor indinavir reduces immature dendritic cell transendothelial migration.

Abstract:

Indinavir (IDV) is a protease inhibitor that successfully suppresses HIV-1 replication as part of anti-retroviral therapy. There is evidence to suggest that IDV may also act non-specifically upon host proteases. In this study we investigated whether IDV could modulate protease-dependent molecules involved in dendritic cell (DC) migration - a pivotal process in immunoregulation. Human monocyte-derived DC were exposed to IDV (IDV-DC) and transendothelial migration (TEM) to inflammatory chemokin...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200323646

Authors


Whelan, KT More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
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Journal:
European journal of immunology
Volume:
33
Issue:
9
Pages:
2520-2530
Publication date:
2003-09-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:6e372f44-1185-4d49-bf8a-a16a26b42a81
Source identifiers:
24892
Local pid:
pubs:24892

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