- Abstract:
-
Indinavir (IDV) is a protease inhibitor that successfully suppresses HIV-1 replication as part of anti-retroviral therapy. There is evidence to suggest that IDV may also act non-specifically upon host proteases. In this study we investigated whether IDV could modulate protease-dependent molecules involved in dendritic cell (DC) migration - a pivotal process in immunoregulation. Human monocyte-derived DC were exposed to IDV (IDV-DC) and transendothelial migration (TEM) to inflammatory chemokin...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/eji.200323646
-
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- Journal:
- European journal of immunology
- Volume:
- 33
- Issue:
- 9
- Pages:
- 2520-2530
- Publication date:
- 2003-09-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:6e372f44-1185-4d49-bf8a-a16a26b42a81
- Source identifiers:
-
24892
- Local pid:
- pubs:24892
- Copyright date:
- 2003
Journal article
The HIV protease inhibitor indinavir reduces immature dendritic cell transendothelial migration.
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