Journal article icon

Journal article

Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4

Abstract:

Fatty acid binding protein 4 (FABP4) is a fatty acid chaperone, which is induced during adipocyte differentiation. Previously we have shown that FABP4 in endothelial cells is induced by the NOTCH1 signalling pathway, the latter of which is involved in mechanisms of resistance to antiangiogenic tumour therapy. Here, we investigated the role of FABP4 in endothelial fatty acid metabolism and tumour angiogenesis. We analysed the effect of transient FABP4 knockdown in human umbilical vein endothel...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/onc.2016.256

Authors


More by this author
Role:
Author
ORCID:
0000-0003-0376-1262
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; Weatherall Insti. of Molecular Medicine
Role:
Author
Expand authors...
Cancer Research UK More from this funder
Breast Cancer Research Foundation More from this funder
More from this funder
Grant:
CA109298, P50 CA083639, P50 CA098258, UH2 TR000943
RGK Foundation More from this funder
Expand funders...
Publisher:
Springer Nature Publisher's website
Journal:
Oncogene Journal website
Volume:
36
Issue:
7
Pages:
912-921
Publication date:
2016-08-29
Acceptance date:
2016-06-01
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
Pmid:
27568980
Source identifiers:
641281
Language:
English
Pubs id:
pubs:641281
UUID:
uuid:6e2e0144-42d6-4654-b715-73a8a42f0f03
Local pid:
pubs:641281
Deposit date:
2018-01-23

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP