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Effects of insulin receptor down-regulation on hexose transport in human erythrocytes.

Abstract:

D-Glucose and D-galactose influx and efflux rates in human erythrocytes were studied using infinite-cis and zero-trans assay methods. It was found that insulin decreased the infinite-cis Km for both D-glucose and D-galactose influx by 44 and 56%, respectively, while the Vmax was unchanged. The Km for D-glucose efflux in the presence of insulin decreased by 47% when compared to controls, and the change in Vmax was statistically insignificant. If insulin receptors were first down regulated, and...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
259
Issue:
22
Pages:
13660-13663
Publication date:
1984-11-05
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:6e2c5536-10eb-4ae0-8470-fa9f0a1e1583
Source identifiers:
482729
Local pid:
pubs:482729

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