Antagonism and bistability in protein interaction networks.

Journal article

A protein interaction network (PIN) is a set of proteins that modulate one another's activities by regulated synthesis and degradation, by reversible binding to form complexes, and by catalytic reactions (e.g., phosphorylation and dephosphorylation). Most PINs are so complex that their dynamical characteristics cannot be deduced accurately by intuitive reasoning alone. To predict the properties of such networks, many research groups have turned to mathematical models (differential equations b...

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Authors: Sabouri-Ghomi, M; Ciliberto, A; Kar, S; Novak, B; Tyson, J

• Publication status: Published
• Journal: Journal of theoretical biology
• Volume: 250
• Issue: 1
• Pages: 209-218
• Publication date: 2008-01-01
• DOI: 10.1016/j.jtbi.2007.09.001
• EISSN: 1095-8541
• ISSN: 0022-5193
• Language: English
• Keywords: Cell Aging; Protein Interaction Mapping; Stochastic Processes; Models, Chemical; Algorithms; Protein Binding; Proteins; Cell Cycle; Cell Cycle Proteins; Saccharomyces cerevisiae