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Wild-type Drosophila melanogaster as an alternative model system for investigating the pathogenicity of Candida albicans.

Abstract:

Candida spp. are opportunistic pathogens in humans, and their systemic infections display upwards of 30% mortality in immunocompromised patients. Current mammalian model systems have certain disadvantages in that obtaining results is time consuming owing to the relatively long life spans and these results have low statistical resolution because sample sizes are usually small. We have therefore evaluated the potential of Drosophila melanogaster as an additional model system with which to disse...

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Publication status:
Published

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Publisher copy:
10.1242/dmm.006619

Authors


Glittenberg, MT More by this author
MacCallum, DM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Disease models and mechanisms
Volume:
4
Issue:
4
Pages:
504-514
Publication date:
2011-07-05
DOI:
EISSN:
1754-8411
ISSN:
1754-8403
URN:
uuid:6dd81487-5d8f-420d-9b82-863d839babc3
Source identifiers:
138815
Local pid:
pubs:138815

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