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Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.

Abstract:

The ubiquitin (Ub)-proteasome system includes a large family of deubiquitinating enzymes (DUBs). Many members are assigned to this enzyme class by sequence similarity but without evidence for biological activity. A panel of novel DUB-specific probes was generated by a chemical ligation method. These probes allowed identification of DUBs and associated components by tandem mass spectrometry, as well as rapid demonstration of enzymatic activity for gene products whose functions were inferred fr...

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Publication status:
Published

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Journal:
Chemistry and biology
Volume:
9
Issue:
10
Pages:
1149-1159
Publication date:
2002-10-01
DOI:
EISSN:
1879-1301
ISSN:
1074-5521
Source identifiers:
25536

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