Integrated genomics point to immune vulnerabilities in pleural mesothelioma

Journal article

Pleural mesothelioma (PM) is a cancer of the pleural surface, which is aggressive and may be rapidly fatal. PM is a rare cancer worldwide, but is a relatively common disease in Turkey. Asbestos exposure is the main risk factor and the most common underlying cause of the disease. There have been significant improvements in diagnoses and treatments of many malignancies; however, there are still therapeutic challenges in PM. In this review, we aimed to increase the awareness of health care professionals, oncologists, and pulmonologists by underlining the unmet needs of patients with PM and by emphasizing the need for a multidisciplinary treatment and management of PM. After reviewing the general information about PM, we further discuss the treatment options for patients with PM using immunotherapy and offer evidence for improvements in the clinical outcomes of these patients because of these newer treatment modalities

Authors: Nastase, A; Mandal, A; Lu, SK; Anbunathan, H; Morris-Rosendahl, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Scientific Reports
• Volume: 11
• Issue: 1
• Pages: 19138-19138
• Publication date: 2021-09-27
• DOI: 10.1038/s41598-021-98414-w
• EISSN: 2045-2322
• ISSN: 2045-2322
• Language: English
• Keywords: Data science; Internal medicine; Pathology; Pleural disease; Gene; Bioinformatics; Computer science; Mesothelioma; Genetics; Computational biology; Genomics; Genome; Medicine; Biology; Respiratory disease