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A randomized, double-blind, placebo-controlled, dose-ranging trial of tafenoquine for weekly prophylaxis against Plasmodium falciparum.

Abstract:

Tafenoquine is a promising new 8-aminoquinoline drug that may be useful for malaria prophylaxis in nonpregnant persons with normal glucose-6-phosphate dehydrogenase (G6PD) function. A randomized, double-blind, placebo-controlled chemoprophylaxis trial was conducted with adult residents of northern Ghana to determine the minimum effective weekly dose of tafenoquine for the prevention of infection by Plasmodium falciparum. The primary end point was a positive malaria blood smear result during t...

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Publication status:
Published

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Publisher copy:
10.1086/367542

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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America More from this journal
Volume:
36
Issue:
5
Pages:
541-549
Publication date:
2003-03-01
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Language:
English
Keywords:
Pubs id:
pubs:81802
UUID:
uuid:6da1d4b7-6d3f-49ba-83b6-db101c9addc1
Local pid:
pubs:81802
Source identifiers:
81802
Deposit date:
2012-12-19

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