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Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)

Abstract:

Naturally acquired clinical immunity to Plasmodium falciparum is partly mediated by antibodies directed at parasite-derived antigens expressed on the surface of red blood cells which mediate disease and are extremely diverse. Unlike children, adults recognize a broad range of variant surface antigens (VSAs) and are protected from severe disease. Though crucial to the design and feasibility of an effective malaria vaccine, it is not yet known whether immunity arises through cumulative exposure...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1007870

Authors


More by this author
Role:
Author
ORCID:
0000-0002-0624-1791
More by this author
Role:
Author
ORCID:
0000-0003-1279-9625
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Role:
Author
ORCID:
0000-0001-7989-2125
More from this funder
Name:
Wellcome Trust
Funding agency for:
Marsh, K
Grant:
077176
Publisher:
Public Library of Science
Journal:
PLoS Pathogens More from this journal
Volume:
15
Issue:
7
Pages:
e1007870
Publication date:
2019-07-01
Acceptance date:
2019-05-24
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pmid:
31260501
Language:
English
Pubs id:
pubs:1028450
UUID:
uuid:6d9f1454-d195-403a-bd40-d9caa44b8b98
Local pid:
pubs:1028450
Source identifiers:
1028450
Deposit date:
2019-07-29

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