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Journal article

Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.

Abstract:

Shaker-like (KV1.1) channels contain a highly conserved Pro-Val-Pro (PVP) motif at the base of S6 that produces a kink in the S6 helices and provides a flexible element thought to be essential for channel gating. The role of proline-induced kinks in transmembrane helices is well known, but the contribution of the small hydrophobic valine between these two prolines is not known, and interestingly, Shab-like (KV2.1) channels possess an isoleucine at this position (PIP). Here we show that the ex...

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Publication status:
Published

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Publisher copy:
10.4161/chan.3.1.7548

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
Journal:
Channels (Austin, Tex.) More from this journal
Volume:
3
Issue:
1
Pages:
39-45
Publication date:
2009-01-01
DOI:
EISSN:
1933-6969
ISSN:
1933-6950

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