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The role of SPINK1 in ETS rearrangement-negative prostate cancers.

Abstract:

ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers ( approximately 10% of total cases). We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier expression can be detected noninvasively in u...

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Publisher copy:
10.1016/j.ccr.2008.04.016

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Journal:
Cancer cell More from this journal
Volume:
13
Issue:
6
Pages:
519-528
Publication date:
2008-06-01
DOI:
EISSN:
1878-3686
ISSN:
1535-6108

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