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Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter.

Abstract:

The influenza virus is a major human and animal pathogen responsible for seasonal epidemics and occasional pandemics. The genome of the influenza A virus comprises eight segments of single-stranded, negative-sense RNA with highly conserved 5' and 3' termini. These termini interact to form a double-stranded promoter structure that is recognized and bound by the viral RNA-dependent RNA polymerase (RNAP); however, no 3D structural information for the influenza polymerase-bound promoter exists. F...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1406056111

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
111
Issue:
32
Pages:
E3335-E3342
Publication date:
2014-08-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:477759
UUID:
uuid:6d727486-32ce-4268-921d-6a82fc9a18d8
Local pid:
pubs:477759
Source identifiers:
477759
Deposit date:
2014-08-12

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