Journal article

Bridge cross-coupling of bicyclo[1.1.0]butanes

Abstract:: Bicyclo[1.1.0]butanes (BCBs) have gained growing popularity in “strain release” chemistry for the synthesis of four-membered-ring systems and para- and meta-disubstituted arene bioisosteres as well as applications in chemoselective bioconjugation. However, functionalization of the bridge position of BCBs can be challenging due to the inherent strain of the ring system and reactivity of the central C–C bond. Here we report the first late-stage bridge cross-coupling of BCBs, mediated by directed metalation/palladium catalysis.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

McNamee, R. E., Dasgupta, A., Christensen, K. E., & Anderson, E. A. (2023). Bridge cross-coupling of bicyclo[1.1.0]butanes. Organic Letters, 26(1), 360–364.

MLA Style

McNamee, R. E., et al. “Bridge Cross-Coupling of Bicyclo[1.1.0]Butanes.” Organic Letters, vol. 26, no. 1, American Chemical Society, 2023, pp. 360–64.

Chicago Style

McNamee, RE, A Dasgupta, KE Christensen, and EA Anderson. 2023. “Bridge Cross-Coupling of Bicyclo[1.1.0]Butanes.” Organic Letters 26 (1): 360–64.
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Files:: McNamee_et_al_2023_Bridge_cross-coupling_of.pdf

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Publisher copy:: 10.1021/acs.orglett.3c04030

Authors

+ McNamee, RE More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Dasgupta, A More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Christensen, KE More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Anderson, EA More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Oxford college:: Jesus College
Role:: Author
ORCID:: 0000-0002-4149-0494

+ Engineering and Physical Sciences Research Council More from this funder

Funder identifier:: https://ror.org/0439y7842
Grant:: EP/S013172/1; EP/L015838/1

Publisher:: American Chemical Society
Journal:: Organic Letters More from this journal
Volume:: 26
Issue:: 1
Pages:: 360-364
Place of publication:: United States
Publication date:: 2023-12-29
Acceptance date:: 2023-12-20
DOI:: 10.1021/acs.orglett.3c04030
EISSN:: 1523-7052
ISSN:: 1523-7060
Pmid:: 38156902

Language:: English
Pubs id:: 1595032
Local pid:: pubs:1595032
Deposit date:: 2024-06-24

Terms of use

Copyright holder:: McNamee et al.
Copyright date:: 2023
Rights statement:: © 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0.

Licence:: CC Attribution (CC BY)

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