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NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells.

Abstract:

A variety of endothelial agonist-induced responses are mediated by rises in intracellular Ca(2+), suggesting that different Ca(2+) signatures could fine-tune specific inflammatory and thrombotic activities. In search of new intracellular mechanisms modulating endothelial effector functions, we identified nicotinic acid adenine dinucleotide phosphate (NAADP) as a crucial second messenger in histamine-induced Ca(2+) release via H1 receptors (H1R). NAADP is a potent intracellular messenger mobil...

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Publication status:
Published

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Authors


Esposito, B More by this author
Gambara, G More by this author
Palombi, F More by this author
D'Alessio, A More by this author
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Journal:
Blood
Volume:
117
Issue:
18
Pages:
4968-4977
Publication date:
2011-05-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:6d6049b2-1b07-455a-bf77-c024815f5f6b
Source identifiers:
120209
Local pid:
pubs:120209

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