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Journal article

Fast measurement of sarcomere length and cell orientation in Langendorff-perfused hearts using remote focusing microscopy.

Abstract:

RATIONALE: Sarcomere length (SL) is a key indicator of cardiac mechanical function, but current imaging technologies are limited in their ability to unambiguously measure and characterize SL at the cell level in intact, living tissue. OBJECTIVE: We developed a method for measuring SL and regional cell orientation using remote focusing microscopy, an emerging imaging modality that can capture light from arbitrary oblique planes within a sample. METHODS AND RESULTS: We present a protocol that u...

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Publication status:
Published

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Journal:
Circulation research
Volume:
113
Issue:
7
Pages:
863-870
Publication date:
2013-09-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Source identifiers:
415873
Language:
English
Keywords:
Pubs id:
pubs:415873
UUID:
uuid:6d1d9cff-d5fa-49de-9065-3a475875c926
Local pid:
pubs:415873
Deposit date:
2013-11-17

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