- Abstract:
-
A theoretical approach for linkage mapping the genome of any higher eukaryote is described. It uses the polymerase chain reaction, oligonucleotides of random sequence and single haploid cells. Markers are defined and then the DNA of a single sperm is broken at random (eg by gamma-rays) and physically split into 3 aliquots. Each aliquot is screened for the presence of each marker. Closely-linked markers are more likely to be found in the same aliquot than unlinked markers. The entire process i...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/nar/17.17.6795
-
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- Journal:
- Nucleic acids research
- Volume:
- 17
- Issue:
- 17
- Pages:
- 6795-6807
- Publication date:
- 1989-09-05
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:6d1ce9e6-af43-4ee4-9dbb-05b87fb1a486
- Source identifiers:
-
13948
- Local pid:
- pubs:13948
- Language:
- English
- Keywords:
- Copyright date:
- 1989
Journal article
Happy mapping: a proposal for linkage mapping the human genome.
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