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Happy mapping: a proposal for linkage mapping the human genome.

Abstract:

A theoretical approach for linkage mapping the genome of any higher eukaryote is described. It uses the polymerase chain reaction, oligonucleotides of random sequence and single haploid cells. Markers are defined and then the DNA of a single sperm is broken at random (eg by gamma-rays) and physically split into 3 aliquots. Each aliquot is screened for the presence of each marker. Closely-linked markers are more likely to be found in the same aliquot than unlinked markers. The entire process i...

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Publication status:
Published

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Publisher copy:
10.1093/nar/17.17.6795

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Nucleic acids research
Volume:
17
Issue:
17
Pages:
6795-6807
Publication date:
1989-09-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:6d1ce9e6-af43-4ee4-9dbb-05b87fb1a486
Source identifiers:
13948
Local pid:
pubs:13948

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