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Oxidative diversification of steroids by nature-inspired scanning glycine mutagenesis of P450BM3 (CYP102A1)

Abstract:

Steroidal compounds are some of the most prescribed medicines, being indicated for the treatment of a variety of conditions including inflammation, heart disease, and cancer. Synthetic approaches to functionalized steroids are important for generating steroidal agents for drug screening and development. However, chemical activation is challenging because of the predominance of inert, aliphatic C–H bonds in steroids. Here, we report the engineering of the stable, highly active bacterial cytoch...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acscatal.0c02077

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
ORCID:
0000-0003-4875-1092
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Name:
Biotechnology and Biological Sciences Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000268
Grant:
BIVMiB008
BB/L024381/1
Publisher:
American Chemical Society
Journal:
ACS Catalysis More from this journal
Volume:
10
Issue:
15
Pages:
8334-8343
Publication date:
2020-06-12
Acceptance date:
2020-06-12
DOI:
EISSN:
2155-5435
Language:
English
Keywords:
Pubs id:
1119112
Local pid:
pubs:1119112
Deposit date:
2020-07-16

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