Journal article
Functional and immunologic mapping of domains of the reticulocyte-binding protein Plasmodium vivax PvRBP2a
- Abstract:
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We previously described a novel Plasmodium vivax invasion mechanism into human reticulocytes via the PvRBP2a-CD98 receptor-ligand pair. Using linear epitope mapping, we assessed the PvRBP2a epitopes involved in CD98 binding and recognized by antibodies from patients who were infected. We identified 2 epitope clusters mediating PvRBP2a-CD98 interaction. Cluster B (PvRBP2a431-448, TAALKEKGKLLANLYNKL) was the target of antibody responses in humans infected by P vivax. Peptides from each cluster were able to prevent live parasite invasion of human reticulocytes. These results provide new insights for development of a malaria blood-stage vaccine against P vivax.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.6MB, Terms of use)
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- Publisher copy:
- 10.1093/infdis/jiae111
Authors
- Publisher:
- Oxford University Press
- Journal:
- Journal of Infectious Diseases More from this journal
- Volume:
- 230
- Issue:
- 3
- Pages:
- e737-e742
- Publication date:
- 2024-03-05
- Acceptance date:
- 2024-03-03
- DOI:
- EISSN:
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1537-6613
- ISSN:
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0022-1899
- Pmid:
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38441336
- Language:
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English
- Keywords:
- Pubs id:
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1784546
- Local pid:
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pubs:1784546
- Deposit date:
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2025-03-11
- ARK identifier:
Terms of use
- Copyright holder:
- Tay et al.
- Copyright date:
- 2024
- Rights statement:
- © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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