Journal article
Directed evolution generates a novel oncolytic virus for the treatment of colon cancer
- Abstract:
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Background Viral-mediated oncolysis is a novel cancer therapeutic approach with the potential to be more effective and less toxic than current therapies due to the agents selective growth and amplification in tumor cells. To date, these agents have been highly safe in patients but have generally fallen short of their expected therapeutic value as monotherapies. Consequently, new approaches to generating highly potent oncolytic viruses are needed. To address this need, we developed a new metho...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 635.2KB)
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- Publisher copy:
- 10.1371/journal.pone.0002409
Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 3
- Issue:
- 6
- Pages:
- ARTN e2409
- Publication date:
- 2008-06-18
- Acceptance date:
- 2008-04-30
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:6d01c32b-c70b-4968-bf65-bf9a33d487e8
- Local pid:
- pubs:175346
- Source identifiers:
-
175346
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Kuhn et al
- Copyright date:
- 2008
- Notes:
- Copyright: © 2008 Kuhn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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