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Directed evolution generates a novel oncolytic virus for the treatment of colon cancer

Abstract:

Background Viral-mediated oncolysis is a novel cancer therapeutic approach with the potential to be more effective and less toxic than current therapies due to the agents selective growth and amplification in tumor cells. To date, these agents have been highly safe in patients but have generally fallen short of their expected therapeutic value as monotherapies. Consequently, new approaches to generating highly potent oncolytic viruses are needed. To address this need, we developed a new metho...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0002409

Authors


Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
3
Issue:
6
Pages:
ARTN e2409
Publication date:
2008-06-18
Acceptance date:
2008-04-30
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:6d01c32b-c70b-4968-bf65-bf9a33d487e8
Local pid:
pubs:175346
Source identifiers:
175346
Deposit date:
2013-11-16

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