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Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.

Abstract:

Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3+/- mice with a diet low in calcium and vitamin D so as to expose any defects in parathyroid function. This led to a higher mortality among Gata3+/- mice compared with Gata3+/+ mice. Compared with their wild-type littermates, Gata3+/- mice had lo...

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Publication status:
Published

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Publisher copy:
10.1172/jci42021

Authors


Grigorieva, IV More by this author
Mirczuk, S More by this author
Gaynor, KU More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Grigorieva, EF More by this author
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Journal:
The Journal of clinical investigation
Volume:
120
Issue:
6
Pages:
2144-2155
Publication date:
2010-06-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:6cf57671-7380-4f53-9235-549fb262929d
Source identifiers:
54777
Local pid:
pubs:54777

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