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Journal article

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.

Abstract:

Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3+/- mice with a diet low in calcium and vitamin D so as to expose any defects in parathyroid function. This led to a higher mortality among Gata3+/- mice compared with Gata3+/+ mice. Compared with their wild-type littermates, Gata3+/- mice had lo...

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Publication status:
Published

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Publisher copy:
10.1172/jci42021

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Journal:
Journal of clinical investigation
Volume:
120
Issue:
6
Pages:
2144-2155
Publication date:
2010-06-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Source identifiers:
54777
Language:
English
Keywords:
Pubs id:
pubs:54777
UUID:
uuid:6cf57671-7380-4f53-9235-549fb262929d
Local pid:
pubs:54777
Deposit date:
2012-12-19

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