Journal article
Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.
- Abstract:
-
Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3+/- mice with a diet low in calcium and vitamin D so as to expose any defects in parathyroid function. This led to a higher mortality among Gata3+/- mice compared with Gata3+/+ mice. Compared with their wild-type littermates, Gata3+/- mice had lo...
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- Publication status:
- Published
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- Publisher copy:
- 10.1172/jci42021
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Authors
Bibliographic Details
- Journal:
- Journal of clinical investigation
- Volume:
- 120
- Issue:
- 6
- Pages:
- 2144-2155
- Publication date:
- 2010-06-01
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- Source identifiers:
-
54777
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:54777
- UUID:
-
uuid:6cf57671-7380-4f53-9235-549fb262929d
- Local pid:
- pubs:54777
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2010
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