Journal article
Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.
- Abstract:
-
Crystallographic analysis of the catalytic domain of PHD finger protein 8 (PHF8), an N(epsilon)-methyl lysine histone demethylase associated with mental retardation and cleft lip/palate, reveals a double-stranded beta-helix fold with conserved Fe(II) and cosubstrate binding sites typical of the 2-oxoglutarate dependent oxygenases. The PHF8 active site is highly conserved with those of the FBXL10/11demethylases, which are also selective for the di-/mono-methylated lysine states, but differs fr...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.febslet.2009.12.055
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Bibliographic Details
- Journal:
- FEBS letters
- Volume:
- 584
- Issue:
- 4
- Pages:
- 825-830
- Publication date:
- 2010-02-01
- DOI:
- EISSN:
-
1873-3468
- ISSN:
-
0014-5793
- Source identifiers:
-
108265
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:108265
- UUID:
-
uuid:6ce5a722-3c8a-483f-9153-239c875353fd
- Local pid:
- pubs:108265
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2010
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