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ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia.

Abstract:

Intratumoral hypoxia is associated with poor prognosis, regardless of the mode of therapy. Cancer cells survive this condition through activating several adaptive signaling pathways, including the integrated stress response (ISR) and autophagy. Activating transcription factor 4 (ATF4) is the major transcriptional mediator of the ISR, which we have shown to be involved in autophagy regulation to protect cells from severe hypoxia. Here we demonstrate that ATF4 orchestrates a program of BH3-only...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Molecular biology reports
Volume:
39
Issue:
12
Pages:
10811-10822
Publication date:
2012-12-01
EISSN:
1573-4978
Source identifiers:
396040
Language:
English
Pubs id:
pubs:396040
UUID:
uuid:6cd781ae-eb57-4fdd-943f-0d0ae05040b1
Local pid:
pubs:396040
Deposit date:
2013-11-17

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