Journal article icon

Journal article

ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia.

Abstract:

Intratumoral hypoxia is associated with poor prognosis, regardless of the mode of therapy. Cancer cells survive this condition through activating several adaptive signaling pathways, including the integrated stress response (ISR) and autophagy. Activating transcription factor 4 (ATF4) is the major transcriptional mediator of the ISR, which we have shown to be involved in autophagy regulation to protect cells from severe hypoxia. Here we demonstrate that ATF4 orchestrates a program of BH3-only...

Expand abstract

Actions


Authors


Phadwal, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Molecular Medicine
Harris, AL More by this author
Journal:
Molecular biology reports
Volume:
39
Issue:
12
Pages:
10811-10822
Publication date:
2012-12-05
EISSN:
1573-4978
URN:
uuid:6cd781ae-eb57-4fdd-943f-0d0ae05040b1
Source identifiers:
396040
Local pid:
pubs:396040
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP