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Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert

Abstract:

A major discovery of recent decades has been the existence of stem cells and their potential to repair many, if not most, tissues. With the aging population, many attempts have been made to use exogenous stem cells to promote tissue repair, so far with limited success. An alternative approach, which may be more effective and far less costly, is to promote tissue regeneration by targeting endogenous stem cells. However, ways of enhancing endogenous stem cell function remain poorly defined. Inj...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1802893115

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
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Grant:
MR/K007939/1 (to M.F., N.J.H. and J.N.)
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Grant:
21190 (to A.I.E.S., M.F., N.J.H., and J.N.)
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Grant:
MSP131411 and KENN151611 (to G.L., A.I.E.S., M.F., N.J.H., and J.N.)
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
19
Pages:
E4463-E4472
Publication date:
2018-04-19
Acceptance date:
2018-04-06
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:840493
URN:
uri:6cd07b87-2994-4a83-801e-08243c46d6a6
UUID:
uuid:6cd07b87-2994-4a83-801e-08243c46d6a6
Local pid:
pubs:840493

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