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Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

Abstract:

LRRK2 mutations produce end-stage Parkinson's disease (PD) with reduced nigrostriatal dopamine, whereas, asymptomatic carriers have increased dopamine turnover and altered brain connectivity. LRRK2 pathophysiology remains unclear, but reduced dopamine and mitochondrial abnormalities occur in aged G2019S mutant knock-in (GKI) mice. Conversely, cultured GKI neurons exhibit increased synaptic transmission. We assessed behavior and synaptic glutamate and dopamine function across a range of ages. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.7554/elife.28377

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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Michael J. Fox Foundation for Parkinson's Research More from this funder
Parkinson Canada More from this funder
Canadian Institutes of Health Research More from this funder
Canada Excellence Research Chairs, Government of Canada More from this funder
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
6
Pages:
Article: e28377
Publication date:
2017-09-20
DOI:
ISSN:
2050-084X
Pubs id:
pubs:730198
URN:
uri:6ccfb960-99db-4599-87e6-9d4cc306e4db
UUID:
uuid:6ccfb960-99db-4599-87e6-9d4cc306e4db
Local pid:
pubs:730198

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