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Journal article

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

Abstract:

LRRK2 mutations produce end-stage Parkinson's disease (PD) with reduced nigrostriatal dopamine, whereas, asymptomatic carriers have increased dopamine turnover and altered brain connectivity. LRRK2 pathophysiology remains unclear, but reduced dopamine and mitochondrial abnormalities occur in aged G2019S mutant knock-in (GKI) mice. Conversely, cultured GKI neurons exhibit increased synaptic transmission. We assessed behavior and synaptic glutamate and dopamine function across a range of ages. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.28377

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Michael J. Fox Foundation for Parkinson's Research More from this funder
Parkinson Canada More from this funder
Canada Excellence Research Chairs, Government of Canada More from this funder
Canadian Institutes of Health Research More from this funder
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
6
Article number:
e28377
Publication date:
2017-09-20
Acceptance date:
2017-09-15
DOI:
ISSN:
2050-084X
Pmid:
28930069
Source identifiers:
730198
Language:
English
Keywords:
Pubs id:
pubs:730198
UUID:
uuid:6ccfb960-99db-4599-87e6-9d4cc306e4db
Local pid:
pubs:730198
Deposit date:
2017-11-02

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