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Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.

Abstract:

Priming of insulin secretory granules for release requires intragranular acidification and depends on vesicular Cl(-)-fluxes, but the identity of the chloride transporter/ion channel involved is unknown. We tested the hypothesis that the chloride transport protein ClC-3 fulfills these actions in pancreatic beta cells. In ClC-3(-/-) mice, insulin secretion evoked by membrane depolarization (high extracellular K(+), sulfonylureas), or glucose was >60% reduced compared to WT animals. This eff...

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Publication status:
Published

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Publisher copy:
10.1016/j.cmet.2009.08.011

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Journal:
Cell metabolism
Volume:
10
Issue:
4
Pages:
309-315
Publication date:
2009-10-05
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
URN:
uuid:6ccc6a1c-3304-4dc3-81aa-f5461f558e4a
Source identifiers:
7317
Local pid:
pubs:7317

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