Journal article
Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis
- Abstract:
- The genome of influenza viruses consists of multiple segments of single stranded negative-sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent RNA polymerase and multiple copies of nucleoprotein, forming viral ribonucleoprotein (vRNP) complexes. It is in the context of these vRNPs that the viral RNA polymerase carries out transcription of viral genes and replication of the viral RNA genome. In this Review, we discuss our current knowledge of the structure of the influenza virus RNA polymerase, how it carries out transcription and replication, and how its activities are modulated by viral and host factors. Furthermore, we discuss how advances in our understanding of polymerase function could help identifying new antiviral targets.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 10.2MB, Terms of use)
-
- Publisher copy:
- 10.1038/nrmicro.2016.87
Authors
+ Lincoln College, Oxford
More from this funder
- Funding agency for:
- te Velthuis, A
- Grant:
- Postdoctoral Fellowship
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Reviews Microbiology More from this journal
- Volume:
- 14
- Pages:
- 479–493
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-05-24
- DOI:
- EISSN:
-
1740-1534
- ISSN:
-
1740-1526
- Pubs id:
-
pubs:627632
- UUID:
-
uuid:6cc31853-9320-4155-b11c-e83bdb990843
- Local pid:
-
pubs:627632
- Source identifiers:
-
627632
- Deposit date:
-
2016-06-13
- ARK identifier:
Terms of use
- Copyright holder:
- E Fodor and A te Velthuis
- Copyright date:
- 2016
- Notes:
- Authors retain copyright. This is the accepted manuscript version of the article. The final version is available online from Nature at: [10.1038/nrmicro.2016.87]
If you are the owner of this record, you can report an update to it here: Report update to this record