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Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis

Abstract:

The genome of influenza viruses consists of multiple segments of single stranded negative-sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent RNA polymerase and multiple copies of nucleoprotein, forming viral ribonucleoprotein (vRNP) complexes. It is in the context of these vRNPs that the viral RNA polymerase carries out transcription of viral genes and replication of the viral RNA genome. In this Review, we discuss our current knowledge of the structure of th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nrmicro.2016.87

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More from this funder
Funding agency for:
te Velthuis, A
Grant:
Postdoctoral Fellowship
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Reviews Microbiology Journal website
Volume:
14
Pages:
479–493
Publication date:
2016-01-01
Acceptance date:
2016-05-24
DOI:
EISSN:
1740-1534
ISSN:
1740-1526
Source identifiers:
627632
Pubs id:
pubs:627632
UUID:
uuid:6cc31853-9320-4155-b11c-e83bdb990843
Local pid:
pubs:627632
Deposit date:
2016-06-13

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