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Probing the structural basis of RecQ helicase function.

Abstract:

RecQ helicases are a ubiquitous family of DNA unwinding enzymes required to preserve genome integrity, thus preventing premature aging and cancer formation. The five human representatives of this family play non-redundant roles in the suppression of genome instability using a combination of enzymatic activities that specifically characterize each member of the family. These enzymes are in fact not only able to catalyze the transient opening of DNA duplexes, as any other conventional helicase,...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpc.2010.03.012

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
Journal:
Biophysical chemistry
Volume:
149
Issue:
3
Pages:
67-77
Publication date:
2010-07-05
DOI:
EISSN:
1873-4200
ISSN:
0301-4622
URN:
uuid:6c927d5f-6123-4c9a-a69d-9170badc704d
Source identifiers:
53301
Local pid:
pubs:53301

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