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Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China

Abstract:

Background Moderate alcohol intake has been associated with reduced cardiovascular risk in many studies, in comparison with abstinence or with heavier drinking. Studies in east Asia can help determine whether these associations are causal, since two common genetic variants greatly affect alcohol drinking patterns. We used these two variants to assess the relationships between cardiovascular risk and genotype-predicted mean alcohol intake in men, contrasting the findings in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S0140-6736(18)31772-0

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Hong Kong Kadoorie Charitable Foundation More from this funder
GlaxoSmithKline More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Journal website
Volume:
393
Issue:
10183
Pages:
1831-1842
Publication date:
2019-04-04
Acceptance date:
2018-07-24
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Pubs id:
pubs:922097
UUID:
uuid:6c82d6de-fa90-42d6-ace8-aa0d7c3568ce
Local pid:
pubs:922097
Deposit date:
2018-09-27

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