Journal article
Vasorelaxation to the HNO donor isopropylamine NONOate in resistance arteries does not require perivascular CGRP
- Abstract:
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HNO donors offer considerable therapeutic potential for the treatment of hypertension-related cardiovascular disorders, particularly heart failure, as they combine an inotropic action with peripheral vasodilation. Angeli’s salt (AS) is the only HNO donor whose mechanism has been studied in depth, and recently AS-vasodilation was suggested to be indirect and due to calcitonin gene-related peptide (CGRP) released from perivascular nerves after HNO activates TRPA1 channels. We investigated resis...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Accepted manuscript, pdf, 116.9KB)
-
- Publisher copy:
- 10.1161/HYPERTENSIONAHA.117.09737
Authors
Funding
+ Royal Society
More from this funder
Funding agency for:
Garland, C
Grant:
Wolfson-Royal Society Merit Award
+ British Heart Foundation
More from this funder
Funding agency for:
Pinkney, A
Dora, K
Grant:
Senior Fellowship in Basic Science
Bibliographic Details
- Publisher:
- American Heart Association Publisher's website
- Journal:
- Hypertension Journal website
- Volume:
- 70
- Issue:
- 3
- Pages:
- 587-593
- Publication date:
- 2017-07-31
- Acceptance date:
- 2017-07-04
- DOI:
- EISSN:
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1524-4563
- ISSN:
-
0194-911X
Item Description
- Keywords:
- Pubs id:
-
pubs:703013
- UUID:
-
uuid:6c7c9b6e-b840-4f55-a7a4-fdd45af2cbaf
- Local pid:
- pubs:703013
- Source identifiers:
-
703013
- Deposit date:
- 2017-07-05
Terms of use
- Copyright holder:
- American Heart Association, Inc
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 American Heart Association, Inc. This is the accepted manuscript version of the article. The final version is available online from the American Heart Association at: https://doi.org/10.1161/HYPERTENSIONAHA.117.09737
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