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Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells

Abstract:

Medical treatments for corticotrophinomas are limited, and we therefore investigated the effects of epigenetic modulators, a new class of anti-tumour drugs, on the murine adrenocorticotropic hormone (ACTH)-secreting corticotrophinoma cell line AtT20. We found that AtT20 cells express members of the bromo and extra-terminal (BET) protein family, which bind acetylated histones, and therefore, studied the anti-proliferative and pro-apoptotic effects of two BET inhibitors, referred to as (+)-JQ1 ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0002-0764-8681
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Publisher:
BioScientifica
Journal:
Endocrine-Related Cancer More from this journal
Volume:
27
Issue:
3
Pages:
163-174
Publication date:
2020-03-01
Acceptance date:
2020-01-13
DOI:
EISSN:
1479-6821
ISSN:
1351-0088
Language:
English
Keywords:
Pubs id:
pubs:1082587
UUID:
uuid:6c581026-fa9a-4abb-ac93-4acb82f34754
Local pid:
pubs:1082587
Source identifiers:
1082587
Deposit date:
2020-01-15

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