Journal article icon

Journal article

Preclinical evaluation of discorhabdin in antiangiogenic and antitumor models

Abstract:

Elements of the hypoxia inducible factor (HIF) transcriptional system, a key regulator of the cellular hypoxic response, are up-regulated in a range of cancer cells. HIF is fundamentally involved in tumor angiogenesis, invasion, and energy metabolism. Inhibition of the transcriptional activity of HIF may be of therapeutic benefit to cancer patients. We recently described the identification of two marine pyrroloiminoquinone alkaloids with potent activity in inhibiting the interaction between t...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.3390/md16070241

Authors


More from this funder
Name:
National Institutes of Health
Publisher:
MDPI
Journal:
Marine Drugs More from this journal
Volume:
16
Issue:
7
Pages:
241
Publication date:
2018-07-19
Acceptance date:
2018-07-16
DOI:
ISSN:
1660-3397
Keywords:
Pubs id:
pubs:871321
UUID:
uuid:6c511d8c-f221-4457-a03e-10a769f12e90
Local pid:
pubs:871321
Source identifiers:
871321
Deposit date:
2018-07-17

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP