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Chain length-dependent cooperativity in fatty acid binding and oxidation by cytochrome P450BM3 (CYP102A1).

Abstract:

Fatty acid binding and oxidation kinetics for wild type P450(BM3) (CYP102A1) from Bacillus megaterium have been found to display chain length-dependent homotropic behavior. Laurate and 13-methyl-myristate display Michaelis-Menten behavior while there are slight deviations with myristate at low ionic strengths. Palmitate shows Michaelis-Menten kinetics and hyperbolic binding behavior in 100 mmol/L phosphate, pH 7.4, but sigmoidal kinetics (with an apparent intercept) in low ionic strength buff...

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Publication status:
Published

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Publisher copy:
10.1007/s13238-011-1082-6

Authors


Publisher:
Higher Education Press
Journal:
Protein and cell More from this journal
Volume:
2
Issue:
8
Pages:
656-671
Publication date:
2011-08-01
DOI:
EISSN:
1674-8018
ISSN:
1674-800X
Language:
English
Keywords:
Pubs id:
pubs:175200
UUID:
uuid:6c4af262-7dab-4f4a-922d-db73844afc64
Local pid:
pubs:175200
Source identifiers:
175200
Deposit date:
2013-02-20

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