The structure of linkage disequilibrium around a selective sweep.

Journal article

The fixation of advantageous mutations by natural selection has a profound impact on patterns of linked neutral variation. While it has long been appreciated that such selective sweeps influence the frequency spectrum of nearby polymorphism, it has only recently become clear that they also have dramatic effects on local linkage disequilibrium. By extending previous results on the relationship between genealogical structure and linkage disequilibrium, I obtain simple expressions for the influe...

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Authors: McVean, G

• Publication status: Published
• Journal: Genetics
• Volume: 175
• Issue: 3
• Pages: 1395-1406
• Publication date: 2007-03-01
• DOI: 10.1534/genetics.106.062828
• EISSN: 1943-2631
• ISSN: 0016-6731
• Language: English
• Keywords: Genetic Variation; Alleles; Mutation; Models, Genetic; Linkage Disequilibrium; Computer Simulation; Selection, Genetic