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Clinical utility of plasma microbial cell-free DNA sequencing for early diagnosis of toxoplasmosis in high-risk patients: a five-patient case series

Abstract:
From 2017 to 2025, we reviewed plasma microbial cell-free DNA sequencing (mcfDNA NGS) results detecting Toxoplasma gondii. Five patients were identified. Median turnaround was 3 days (2–5). mcfDNA initiated therapy in two and supported empiric treatment in three but required clinical context for interpretation.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1017/ash.2026.10382

Authors

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Role:
Author
ORCID:
0000-0002-5405-7067
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-0333-1070


Publisher:
Cambridge University Press
Journal:
Antimicrobial Stewardship & Healthcare Epidemiology More from this journal
Volume:
6
Issue:
1
Article number:
e134
Publication date:
2026-05-11
Acceptance date:
2026-03-23
DOI:
EISSN:
2732-494X
ISSN:
2732-494X


Language:
English
Source identifiers:
4031973
Deposit date:
2026-05-11
ARK identifier:
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