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Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs

Abstract:

Glycosylation of therapeutic proteins has a profound impact on their safety and efficacy. Many factors shape the glycosylation of biotherapeutics, ranging from expression systems and cell culture processes to downstream purification strategies. Various analytical technologies have been developed to address questions concerning different aspects of glycosylation. Informatics tools are also crucial for a systematic understanding of the glycosylation processes. Hence, an integrated approach is r...

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Publication status:
In press
Peer review status:
Peer reviewed

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Agency for Science, Singapore More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Drug Discovery Today Journal website
Publication date:
2016
DOI:
ISSN:
1878-5832
URN:
uuid:6c48a030-6ab4-494f-96f3-691a7d8caa01
Source identifiers:
597722
Local pid:
pubs:597722

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