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Genetics HLA: the major human histocompatibility system.

Abstract:

The HLA system was first defined as a cell surface genetic polymorphism with the aim of using it for transplantation matching. The originally defined specificities of the system, usually identified by a microcytotoxicity assay on peripheral blood lymphocytes, are controlled by the alleles of three closely linked loci HLA-A, B and C. These loci are highly polymorphic with at least 19 A alleles, 26 B alleles and 5 C alleles defined. There is extensive cross reaction amongst the determinants con...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.1978.0059

Authors


Bodmer, WF More by this author
Barnstable, CJ More by this author
Bodmer, JG More by this author
Journal:
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain)
Volume:
202
Issue:
1146
Pages:
93-116
Publication date:
1978-06-05
DOI:
EISSN:
1471-2954
ISSN:
0080-4649
URN:
uuid:6c45de21-39ea-4a03-8af5-ccb117ab8320
Source identifiers:
487624
Local pid:
pubs:487624

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