Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.

Journal article

Interferon consensus sequence binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Mice with a null mutation of ICSBP exhibit two prominent phenotypes related to previously described activities of the IRF family. The first is enhanced susceptibility to virus infections associated with impaired production of IFN(gamma). The second is deregulated hematopoiesis in both ICSBP-/- and ICSBP+/- mice that manifests as a syndrome similar to human ch...

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Authors: Holtschke, T; Löhler, J; Kanno, Y; Fehr, T; Giese, N

• Publication status: Published
• Journal: Cell
• Volume: 87
• Issue: 2
• Pages: 307-317
• Publication date: 1996-10-01
• DOI: 10.1016/S0092-8674(00)81348-3
• EISSN: 1097-4172
• ISSN: 0092-8674
• Language: English
• Keywords: Syndrome; Neoplasm Transplantation; Blast Crisis; Cytotoxicity, Immunologic; Interferon Regulatory Factors; Virus Diseases; Immunologic Deficiency Syndromes; Transcription Factors; Gene Expression Regulation; Carrier Proteins; Animals; Hematopoiesis; Repressor Proteins; Immunity, Cellular; Interferon-alpha; Interferons; Leukemia, Experimental; Mice, Knockout; Interferon-beta; Mice; Leukemia, Myelogenous, Chronic, BCR-ABL Positive