Cell-cell communication in the vessel wall.

Journal article

Abstract:: Intercellular communication between cells within the blood vessel wall plays an important role in the control of artery diameter. The endothelial cells lining the lumen of arteries can evoke smooth muscle hyperpolarization both by the release of a factor (EDHF) and by direct cell-cell coupling through gap junctions. Hyperpolarizing current can spread rapidly to cause widespread vasodilatation, and thus increase blood flow to that segment. In addition to the spread of current, small molecules,...
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Institution:

University of Oxford

Division:

MSD

Department:

Pharmacology

Role:

Author

Language:: English
Keywords:: Signal Transduction

Potassium Channels

Sympathetic Nervous System

Regional Blood Flow

Gap Junctions

Connexins

Endothelium, Vascular

Cell Communication

Rats

Arteries

Animals

Muscle, Smooth, Vascular
Pubs id:: pubs:106327
UUID:: uuid:6c10147d-40fc-4721-832c-84e2c7b2d6cd
Local pid:: pubs:106327
Source identifiers:: 106327
Deposit date:: 2012-12-19

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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